Scientists have had a breakthrough developed a method to eradicate cancer cells as effectively as widely-accepted treatments, like chemotherapy — without the radiation treatment’s notorious adverse effects and toxicity — and this, with a very low risk of the disease returning. Cancer, in its multifarious forms, is still the planet’s second-most prolific killer — responsible for one in six deaths worldwide.
It is called as Caspase Independent Cell Death (CICD), the method annihilated all cancer cells, destroying whole tumors — previously the results were unattainable — nearly eliminating the instance of cancer recurrence in experimental models employed by scientists with University of Glasgow.
CICD, may be a more effective way to treat cancer than apoptosis — a process of killing cancerous cells, common to radiation, immunotherapy, and chemotherapy, which activates proteins known as caspases said by Dr. Stephen Tait. This mechanism has the potential to dramatically improve the effectiveness of anti-cancer therapy and reduce unwanted toxicity.
According to Sky News, “When cancer cells are killed through CICD, they alert the immune system through the release of inflammatory proteins. The immune system can then attack tumour cells that were not killed during the initial treatment. “While colorectal cancer cells were used by researchers, the benefits of CICD may also apply to a wide-range of cancer types.”
Chemotherapy and other treatments not only maintain a nasty reputation for insufferable nausea, weakness, exhaustion, and similar noxious effects, but frequently fail to eliminate all cancerous cells, leaving a toxic environment sufficient for redevelopment of the disease.
Although many cancer treatments work by triggering apoptosis, that method sometimes fails to finish the job and instead may lead to the tumor becoming harder to treat. This new research suggests there could be a better way to kill cancer cells which, as an added bonus, also activates the immune system.
Even barring successful human trials, that CICD may eliminate myriad concurrent illnesses of chemotherapy isn’t the treatment’s sole appeal: A study in July found chemotherapy — the treatment, itself — increases aggression in breast cancers, elevating the odds of metastasis. Science reported on the findings at the time.
The blood vessels of patients receiving chemotherapy drugs have more ‘entry points’ through which cancer cells can get into the blood flow and disperse throughout the body, scientists report today in Science Translational Medicine. In mice with breast cancer, chemotherapy shrinks the primary tumor but boosts the number of cancer cells in the lungs and circulating the body.”
Researchers may have a heavy workload ahead to render CICD efficacious for the eradication of cancer in humans, but the model is certainly something to look for in the future.